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The African clawed frog (Xenopus laevis) is a species of South African aquatic frog of the genus Xenopus. Its
African clawed frog

African Clawed frog-snakes1000000

name is derived from the three short claws on each hind foot, which it uses to tear apart its food. The word
Xenopus means "strange foot" and laevis means "smooth".

African clawed frogs can grow up to a length of 5 in (12 cm). They have a flattened head and body, but no tongue or external ears.

The species is found throughout most of Africa, and in isolated, introduced populations in North America, South America, and Europe. This toad like frog has also been introduced into small areas of the UK with around 25 breeding pairs. All species of the Pipidae family are tongueless, toothless and completely aquatic. They use their hands to shove food in their mouths and down their throats and a hyobranchial pump to draw or suck food in their mouth. Pipidae have powerful legs for swimming and lunging after food. They also use the claws on their feet to tear pieces of large food. They lack true ears but have lateral lines running down the length of the body and underside, which is how they can sense movements and vibrations in the water. They use their sensitive fingers, sense of smell, and lateral line system to find food. Pipidae are scavengers and will eat almost anything living, dying or dead and any type of organic waste.

DescriptionEdit

These frogs are plentiful in ponds and rivers within the south-eastern portion of Sub-Saharan Africa. They are aquatic and are often greenish-grey in color. Albino varieties are commonly sold as pets. “Wild-type” African Clawed Frogs are also frequently sold as pets, and often incorrectly labeled as a Congo Frog or African Dwarf Frog because of similar colorings. They are easily distinguished from African Dwarf Frogs because African Clawed Frogs have webbing only on their hind feet while African Dwarf Frogs have webbing on all four feet. They reproduce by laying eggs. Also, the clawed frogs are the only amphibians to have actual (though small) claws.

The average life-span of these frogs ranges from 5 to 150 years with some individuals recorded to have lived for 20–25 years. They shed their skin every season, and eat their own shedded skin.

Although lacking a vocal sac, the males make a mating call of alternating long and short trills, by contracting the intrinsic laryngeal muscles. Females also answer vocally, signaling either acceptance (a rapping sound) or rejection (slow ticking) of the male. This frog has smooth slippery skin which is multicolored on its back with blotches of olive gray or brown. The underside is creamy white with a yellow tinge.

Male and female frogs can be easily distinguished through the following differences. Male frogs are usually about 20% smaller than females, with slim bodies and legs. Males make mating calls to attract females, sounding very much like a cricket calling underwater. Females are larger than the males, appearing far more plump with hip-like bulges above their rear legs (where their eggs are internally located). While they do not sing or call out like males do, they do answer back (an extremely rare phenomenon in the animal world)

Both males and females have a cloaca, which is a chamber through which digestive and urinary wastes pass and through which the reproductive systems also empty. The cloaca empties by way of the vent which in reptiles and amphibians is a single opening for all three systems.

In the wildEdit

In the wild, Xenopus laevis are native to wetlands, ponds and lakes across arid/semiarid regions of southern Africa. Xenopus laevis and Xenopus muelleri occur along the western boundary of the Great African Rift. The people of the sub-Saharan are generally very familiar with this frog, and some cultures use it as a source of protein, an aphrodisiac, or as fertility medicine. Wild Xenopus are much larger than their captive bred counterparts.

Use in researchEdit

Although X. laevis does not have the short generation time and genetic simplicity generally desired in genetic model organisms, it is an important model organism in developmental biology. X. laevis takes 1 to 2 years to reach sexual maturity and, like most of its genus, it is tetraploid. However, it does have a large and easily manipulable embryo. The ease of manipulation in amphibian embryos has given them an important place in historical and modern developmental biology. A related species, Xenopus tropicalis, is now being promoted as a more viable model for genetics. Roger Wolcott Sperry used X. laevis for his famous experiments describing the development of the visual system. These experiments led to the formulation of the Chemoaffinity hypothesis.

Extracts from the eggs of X. laevis frogs are also commonly used for biochemical studies of DNA replication and repair, as these extracts fully support DNA replication and other related processes in a cell-free environment which allows easier manipulation. Xenopus oocytes provide an important expression system for molecular biology. By injecting DNA or mRNA into the oocyte or developing embryo, scientists can study the protein products in a controlled system. This allows rapid functional expression of manipulated DNAs (or mRNA). This is particularly useful in electrophysiology, where the ease of recording from the oocyte makes expression of membrane channels attractive. One challenge of oocyte work is eliminating native proteins that might confound results, such as membrane channels native to the oocyte. Translation of proteins can be blocked or splicing of pre-mRNA can be modified by injection of Morpholino antisense oligos into the oocyte (for distribution throughout the embryo) or early embryo (for distribution only into daughter cells of the injected cell).

The first vertebrate ever to be cloned was an African clawed frog.

Additionally, several African clawed frogs were present on the space shuttle Endeavour (which was launched into space on September 12, 1992) so that scientists could test whether reproduction and development could occur normally in zero gravity.

X. laevis is also notable for its use in the first well-documented method of pregnancy testing when it was discovered that the urine from pregnant women induced X. laevis oocyte production. Human chorionic gonadotropin (HCG) is a hormone found in substantial quantities in the urine of pregnant women. Today, commercially available HCG is injected intoXenopus males and females to induce mating behavior and to breed these frogs in captivity at any time of the year.

As petsEdit

Xenopus laevis have been kept as pets and research subjects since as early as the 1950s. They are extremely hardy and long lived, having been known to live up to 20 or even 30 years in captivity.

African Clawed Frogs are frequently mislabeled as African Dwarf Frogs in pet stores. The astute pet owner will recognize the difference, however, because of the following characteristics:

 African clawed frogs have a smooth skin , African dwarf frogs have a rougher texture.


  • Dwarf frogs have four webbed feet. African Clawed Frogs have webbed hind feet while their front feet have autonomous digits.
  • African Clawed frogs are often found in albino varieties. African Dwarf Frogs have an albino morp which is uncommon though available in the US pet trade .
  • African Dwarf Frogs have eyes positioned on the side of their head, while African Clawed Frogs have eyes on the top of their heads
  • African Clawed Frogs have curved, flat snouts. The snout of an African Dwarf Frog is pointed.

Introducution as pests to other countriesEdit

African Clawed Frogs are voracious predators and easily adapt to many habitats. For this reason, they can easily become harmful invasive species. They can travel short distances to other bodies of water, and some have even been documented to survive mild freezes. They have been shown to devastate native populations of frogs and other creatures by eating their young.

In 2003, Xenopus frogs were discovered in a pond at San Francisco's Golden Gate Park. Much debate now exists in the area on how to exterminate these creatures and keep them from spreading. It is unknown if these frogs entered the San Francisco ecosystem through intentional release or escape into the wild.

Due to incidences in which these frogs were released and allowed to escape into the wild, African Clawed Frogs are illegal to own, transport or sell without a permit in the following US states: Arizona, California, Kentucky, Louisiana, New Jersey, North Carolina, Oregon, Virginia, Hawaii, Nevada, and Washington state. However, it is legal to own Xenopus laevis in Canada.

Feral colonies of Xenopus laevis exist in South Wales, UK, where they were studied as an invasive species. There is also a population in Bedford that has existed for over 100 years as they are able to breed in the UK's climate. Luckily for native wildlife, the species has not spread much further and other colonies are periodically found in the UK but are eradicated to prevent them from becoming established. 

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